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目的研究食管癌患者血清胃液脑肠肽变化意义．方法用放射免疫法测定２５例中晚期食管癌患者血清胃液中物质Ｐ（ＳＰ），β内啡肽（βＥＰ），血管活性肠肽（ＶＩＰ），胃动素（ＭＴＬ），促胃液素（ＧＴ）和亮脑啡肽（ＬＥＫ）含量，并以２７例相当的正常人作对照．结果食管癌患者血清，胃液ＳＰ（ｐｍｏｌ／Ｌ，８８０±５４７ｖｓ３８７±２０９，Ｐ＜００１；２３０±８０ｖｓ１８２±７３，Ｐ＜００５）βＥＰ（ｎｇ／Ｌ，６１７±２６４ｖｓ３６６±２０８，Ｐ＜００１；５１７±１６１ｖｓ３０３±１２０，Ｐ＜００１），胃液ＶＩＰ（ｎｇ／Ｌ，８８１±１４３ｖｓ６５９±１９８，Ｐ＜００１），ＭＴＬ（ｎｇ／Ｌ，２０４９±４２７ｖｓ１５３５±２７２，Ｐ＜００１），ＬＥＫ（ｎｇ／Ｌ，５５５±１５ｖｓ３１８±１１６，Ｐ＜００１）含量显著高于正常人，而血清胃液ＧＴ（ｎｇ／Ｌ，３６５±２３１ｖｓ６１０±２２５，Ｐ＜００１；１９±１０ｖｓ３４±２０，Ｐ＜００１）含量则显著低于正常人，且血清胃液ＳＰ，βＥＰ升高和ＧＴ降低呈正相关（Ｐ＜００５）．结论晚期食管癌患者血清?
3. Objective To study the significance of changes in serum gastric and intestinal peptide in esophageal cancer patients. Methods Radioimmunoassay was used to determine the contents of P (SP), β-endorphin (β-EP), vasoactive intestinal peptide (VIP), motilin (MTL) and gastric juice in 25 patients with advanced esophageal cancer. Contents of prime (GT) and leucoenkephalin (LEK) were compared with 27 normal controls. Results Esophageal cancer patients serum, gastric juice SP (pmol/L, 880±547vs387±209, P<001; 230±80vs182±73, P<0 05) βEP (ng/L, 617±264 vs 366±208, P<001; 517±161 vs303±120, P<001 ), Gastric fluid VIP (ng/L, 881±143vs659±198, P<001), MTL (ng/L, 2049±427 vs 1535±272, P<001), LEK(ng/L,555±15vs318±116, P<001) content was significantly higher than normal, while serum gastric fluid GT (ng/L, 365) ±231vs610±225, P<001; 19±10vs34±20, P<001) content is significantly lower Normal, and the serum gastrin SP, βEP raised and lowered GT positive correlation (P <005). Conclusions Serum of patients with advanced esophageal cancer?