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DNA 疫苗在临床应用前需进行体内药代动力学试验,由于 DNA 疫苗是一类特殊的生物制品,故其药代动力学特性不同于通常的药物。随着分子生物学技术的迅速发展,研究 DNA 疫苗药代动力学的方法也在不断改进。本文就 DNA 疫苗药代动力学特点及其研究方法的新进展作一综述。
DNA vaccines require in vivo pharmacokinetics before clinical application. Since DNA vaccines are a kind of special biological products, their pharmacokinetic properties are different from the usual drugs. With the rapid development of molecular biology techniques, the methods of studying the pharmacokinetics of DNA vaccines are also being improved. In this paper, the characteristics of DNA vaccine pharmacokinetics and the progress of its research methods are reviewed.