二甲基氯硅烷与硅胶表面反应，形成牢固的 Ｓｉ Ｈ 键之后，连接上活泼的中间体—— 烯丙基缩甘油醚作为柔软的分子臂，最后接上二乙基氨基，由此制得了新型的离子交换硅胶键合相。经漫反射红外光谱、元素分析和高效液相色谱法对键合相进行了鉴定和评价。结果表明：键合反应按预定路线进行，键合相具有较好的色谱性能。此种方法可有效地运用于无孔硅胶填料的制备。 Dimethylchlorosilane and silica gel surface reaction to form a solid Si H bond, connected to the lively intermediate - allyl glycidyl ether as a soft molecular arm, and finally connected to diethylamino, thus prepared New ion exchange silica bonded phase. The bonding phase was identified and evaluated by diffuse reflectance infrared spectroscopy, elemental analysis and high performance liquid chromatography. The results show that the bonding reaction proceeds according to a predetermined route, and the bonded phase has good chromatographic performance. This method can be effectively applied to the preparation of non-porous silica gel packing.