两性霉素B对全身性霉菌感染很有临床价值,但不良反应较多,特别是肾毒性。动物试验和临床研究指出,甘露醇可防止这种肾毒性。机理是它扩张肾小管,保持肾小球滤过率,促进肾小管的清除,从而缩短药物与肾小管的接触时间。参考用法:患者数年前有两性霉素B肾毒性反应史,再次接受该药治疗,剂量 Amphotericin B is clinically valuable for systemic fungal infections but has more adverse reactions, especially nephrotoxicity. Animal experiments and clinical studies indicate that mannitol prevents this nephrotoxicity. Mechanism is that it expands the tubules, maintain glomerular filtration rate, promote tubule clearance, thereby shortening the contact time of drugs and tubules. Reference usage: a few years ago the patient had a history of amphotericin B nephrotoxic reaction, again receiving the drug treatment, the dose