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目的:研究分析习惯性流产患者血清转移生长因子-β1(TGF-β1)、抗子宫内膜抗体(Em Ab)、肿瘤坏死因子α(TNF-α)及红细胞免疫、细胞免疫的变化情况。方法:选取2011年9月~2013年7月该院收治的37例习惯性流产患者为观察组,并以同期的37例健康育龄妇女为对照组,然后将两组的血清TGF-β1、Em Ab、TNF-α及红细胞免疫、细胞免疫指标水平进行检测与比较,同时比较观察组中早期与晚期、原发性与继发性患者的检测水平。结果:观察组的血清TGF-β1、Em Ab、CD4+、CD4/CD8、CD56+及免疫黏附促进因子(FEER)、红细胞C3b受体(RBC-C3bR)、免疫黏附肿瘤细胞(RIT)高于对照组,血清TNF-α及CD8+则低于对照组,而早期与晚期习惯性流产患者之间差异均有统计学意义(均P<0.05),而原发性与继发性患者之间差异无统计学意义(P>0.05)。结论:习惯性流产患者存在明显的血清TGF-β1、Em Ab、TNF-α及红细胞免疫、细胞免疫的异常,且早期与晚期患者之间存在明显的差异。
OBJECTIVE: To study the changes of serum immunological and cellular immunity in patients with habitual abortion, and to study the changes of serum levels of TGF-β1, Em Ab, TNF-α and erythrocyte. Methods: From September 2011 to July 2013, 37 cases of habitual abortion treated in our hospital were selected as the observation group. 37 healthy women of childbearing age were enrolled as the control group. Serum levels of TGF-β1, Em Ab, TNF-α, erythrocyte immunity and cellular immunity were detected and compared. The detection levels of early and late, primary and secondary patients in the observation group were also compared. Results: The serum levels of TGF-β1, Em Ab, CD4 +, CD4 / CD8, CD56 + and FEER, RBC-C3bR and RIT in the observation group were higher than those in the control group , Serum TNF-α and CD8 + were lower than those in the control group, but the difference between the early and late habitual abortion patients was statistically significant (all P <0.05), but no significant difference between the primary and secondary patients Significance (P> 0.05). Conclusion: There are obvious serum levels of TGF-β1, Em Ab, TNF-α, erythrocyte and cellular immunity in patients with habitual abortion, and there are obvious differences between early and late patients.