多器官功能障碍综合征(Multiple organ dysfunction sy-drom, MODS)迄今为止仍是ICU的第一死因。近年来人们对MODS进行了广泛深入的研究,认为炎性介质在MODS的演变过程中起关键作用,提出了介质治疗的新观点,现综述如下。1 MODS概念的变更 1973年Tilney将两个或两个以上的器官同时或先后发生功能衰竭,称为多器官衰竭(Multiple organ failure,MOF)。1991年美国ACCP/SCCM芝加哥会议建议将MOF改为多器 Multiple organ dysfunction syndrome (MODS) is by far the first cause of death in the ICU. In recent years, extensive and in-depth research has been carried out on MODS. The inflammatory mediators play a key role in the evolution of MODS, and new ideas of media therapy are proposed, which are summarized as follows. Changes in the concept of MODS 1973 Tilney will be two or more organs simultaneously or successively failure, known as multiple organ failure (Multiple organ failure, MOF). In 1991, the ACCP / SCCM meeting in Chicago proposed to change MOF to multi-device