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目的:本文主要对自身免疫性肝病的临床特性以及其免疫学特点进行研究,以提高该病的认识和诊断水准。方法:选取我院于2010年1月~2013年12月期间收治的自身免疫性肝病患者82例患者的临床症状、体征以及免疫学检查资料进行回顾性分析,探究自身免疫性肝病的临床以及免疫学特性。结果:经过对所有患者的资料的分析和研究,男青年多发原发性硬化性胆管炎;中年女性多发原发性胆汁性肝硬化及其重叠综合征、自身免疫性肝炎。另外在临床表现上,以上几种疾病的黄疸发生率分别为80%、78%、67%、85%,皮肤瘙痒的发生率分别为80%、56%、60%、44%。但是自身免疫性肝炎、原发性胆汁性肝硬化与原发性胆汁性肝硬化重叠综合征患者之间的年龄、性别、黄疸、皮肤瘙痒等症状并无明显差异,P>0.05。结论:自身免疫性肝病在临床上较为常见,患者常伴发肝外自身免疫性疾病;在诊断上应该综合临床、生化、自身抗体以及病理组织学等指标[1]。
OBJECTIVE: In this paper, the clinical characteristics of autoimmune liver disease and its immunological characteristics are studied in order to improve the level of awareness and diagnosis of the disease. Methods: 82 patients with autoimmune liver disease admitted in our hospital from January 2010 to December 2013 were retrospectively analyzed in clinical symptoms, signs and immunological examinations to explore the clinical and immunological characteristics of autoimmune liver disease Learn characteristics. Results: After analysis and study of the data of all patients, young men with multiple primary sclerosing cholangitis; middle-aged women with multiple primary biliary cirrhosis and its overlap syndrome, autoimmune hepatitis. In addition, clinical manifestations, the incidence of jaundice in the above diseases were 80%, 78%, 67%, 85%, the incidence of pruritus were 80%, 56%, 60%, 44%. However, autoimmune hepatitis, primary biliary cirrhosis and primary biliary cirrhosis overlap syndrome patients age, gender, jaundice, pruritus and other symptoms and no significant difference, P> 0.05. Conclusions: Autoimmune liver disease is more common in clinic. Patients often have extrahepatic autoimmune diseases. Clinical, biochemical, autoantibodies and histopathology should be integrated in diagnosis [1].