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目的:探讨肿瘤坏死因子受体相关因子1-补体C5(TRAF1-C5)基因rs3761847位点多态性与东亚人群类风湿性关节炎(RA)的关联性。方法:双人同时检索PubMed、EMBase、中国生物医学文献服务系统数据库、中国知网及万方数据库,筛选出有关TRAF1-C5基因与东亚人群RA的病例对照研究,使用STATA软件进行数据分析,计算等位基因A与G、纯合子(AA与GG)、杂合子(GA与GG)、显性模型(GA+AA与GG)、隐性模型(AA与GA+GG)与东亚人群RA关联性的OR值,同时进行异质性分析及亚组分析。结果:纳入符合入选标准的文献5篇,共包括病例组7 438例及对照组5 593例。Meta分析结果表明rs3761847位点多态性与东亚人群RA无明显关联性,但I2>50%,存在异质性,故使用亚组分析,发现中国及日本人群的RA与rs3761847位点多态性具有关联性,但未在韩国人群发现这种关联性。结论:TRAF1-C5基因rs3761847位点多态性与中国及日本人群的RA存在关联性,但整体东亚人群是否与之关联仍需多中心、大样本、同质性的病例对照研究。
Objective: To investigate the association of rs3761847 polymorphism of TRAF1-C5 gene with rheumatoid arthritis (RA) in East Asia. Methods: Two people simultaneously searched PubMed, EMBase, China Biomedical Literature Service System Database, CNKI and Wanfang Database, screened the case-control study of TRAF1-C5 gene and RA in East Asia, used STATA software for data analysis, calculation and so on A and G, homozygous (AA and GG), heterozygous (GA and GG), dominant (GA + AA and GG), recessive (AA and GA + GG) OR value, while heterogeneity analysis and subgroup analysis. Results: There were 5 articles that met the inclusion criteria, including 7 438 cases in the case group and 5 593 cases in the control group. Meta analysis showed that rs3761847 locus polymorphism and East Asian RA no significant correlation, but I2> 50%, there is heterogeneity, so the use of subgroup analysis found that China and Japan population RA and rs3761847 polymorphism Relevant but not found in Korean population. CONCLUSIONS: The rs3761847 polymorphism of TRAF1-C5 gene is associated with RA in Chinese and Japanese populations. However, whether the whole East Asian population is associated with it still needs a case-control study with multiple centers, large samples and homogeneity.