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子宫内膜癌为女性生殖道三大恶性肿瘤之一,近年来随着肥胖、糖尿病、老龄化增加以及倡导良性子宫疾病尽量保留子宫等影响,其发病率明显增高。其发病机制,一般认为与子宫内膜长期受雌激素作用而缺少孕激素抑制有关,然而子宫内膜癌患者平均发病年龄为60岁,大多数为低雌激素的绝经后妇女,说明存在其他的机制。据文献,mTOR、HIF-1a和IL-17参与子宫内膜癌的发生和发展,在其演进中扮演着重要角色。mTOR信号影响Th17细胞的分化,Th17细胞高水平分泌IL-17,而这种影响与HIF-1a的上调有关,推断mTOR、HIF-1a及IL-17在子宫内膜癌中的表达应具有相关性。联合检测mTOR、HIF-1a及IL-17在子宫内膜癌中的表达,其敏感度及准确率可能高于单个细胞因子或任何两种细胞因子检测组合,为今后临床对子宫内膜癌的病情评估、治疗及预后判断提供新的、更有效的检测指标。
Endometrial cancer is one of the three major malignant tumors of the female genital tract. In recent years, with the increase of obesity, diabetes, aging and the promotion of benign uterine diseases, the uterus is retained as much as possible and the incidence rate is significantly higher. The pathogenesis is generally believed that the endometrium long-term effects of estrogen and the lack of progesterone inhibition, but the average age of onset of endometrial cancer patients aged 60 years, most of the low estrogen-lowering postmenopausal women, indicating the existence of other mechanism. According to the literature, mTOR, HIF-1a and IL-17 participate in the occurrence and development of endometrial cancer and play an important role in their evolution. The mTOR signal influences the differentiation of Th17 cells and Th17 cells secrete high levels of IL-17, and this effect is related to the up-regulation of HIF-1a. It is concluded that the expression of mTOR, HIF-1a and IL-17 in endometrial carcinoma should be correlated Sex. Combined detection of mTOR, HIF-1a and IL-17 expression in endometrial cancer, the sensitivity and accuracy may be higher than a single cytokine or any combination of two cytokines for future clinical evaluation of endometrial cancer Disease assessment, treatment and prognosis to provide new and more effective detection of indicators.