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用被乙醇处置过的雄性费歇尔344大鼠来研究红参提取物对乙醇代谢的影响。给大鼠口服水溶性人参(200mg/kg),对照组给予同等剂量的水,随即用50％的乙醇给大鼠口服(3.2g/kg)或腹腔注射(1.5g/kg)。在给药前和给药后0.5、1、2、3、4和5小时分别从大鼠尾部动脉抽取一定量血液,测得一定的数值,绘制成血浆浓度—时间曲线(0-5小时)。发现,对于经口给予乙醇的大鼠来说,口服人参组血浆中乙醇的浓度——时间曲线下的平均面积比水对照组减少21.0％,而对于腹腔注射乙醇的大鼠来说,人参组与水对照组的乙醇浓度——时间曲线下的面积无显著区别。说明,大鼠血浆中乙醇浓度在口服乙醇的同时加用人参将比单独口服乙醇要低。而口服人参对经腹腔注射乙醇的大鼠来说,其血浆中乙醇的浓度不受影响。
The effect of red ginseng extract on ethanol metabolism was studied using male Fisher 344 rats that had been treated with ethanol. Rats were orally administered with water-soluble ginseng (200 mg/kg), and the control group was given the same dose of water, followed by oral administration (3.2 g/kg) or intraperitoneal injection (1.5 g/kg) with 50% ethanol. A certain amount of blood was drawn from the tail artery of rats before and at the time of administration at 0.5, 1, 2, 3, 4 and 5 hours after administration, and certain values were measured and plotted as plasma concentration-time curves (0-5 hours). . It was found that the average area under the ethanol-concentration-time curve in oral ginseng group rats was 21.0% lower than that of the water control group in rats given oral ethanol, while the rats in the intraperitoneal injection of ethanol were found to have a lower average area. There was no significant difference in the area under the ethanol concentration-time curve with the water control group. This indicates that ethanol concentration in rat plasma will be lower when oral ethanol is used together with ginseng than oral alcohol alone. Oral ginseng was not affected by the concentration of ethanol in the plasma of rats injected intraperitoneally with ethanol.