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目的探讨采用顺铂腹腔热灌注联合紫杉醇静脉化疗治疗晚期卵巢癌的治疗效果,为临床应用提供理论基础及借鉴。方法 46例晚期卵巢癌患者随机分为对照组和试验组。试验组24例,采用顺铂腹腔热灌注联合紫杉醇静脉化疗;对照组22例,采用顺铂及紫杉醇分别静脉滴注。两组均进行为期6个月的治疗,比较患者不良反应发生率及肿瘤控制情况。结果试验组肿瘤控制总有效率79.2%显著高于对照组50.0%,差异具有统计学意义(P<0.05),不良反应发生率明显低于对照组,差异具有统计学意义(P<0.05),严重程度降低。结论顺铂腹腔热灌注联合紫杉醇静脉化疗治疗晚期卵巢癌的疗效显著,值得临床推广应用。
Objective To investigate the therapeutic effect of cisplatin intraperitoneal hyperthermic perfusion combined with paclitaxel intravenous chemotherapy in the treatment of advanced ovarian cancer and provide a theoretical basis and reference for clinical application. Methods 46 patients with advanced ovarian cancer were randomly divided into control group and experimental group. Twenty-four patients in the experimental group were treated with cisplatin intraperitoneal hyperthermic perfusion combined with paclitaxel intravenous chemotherapy and 22 patients in the control group received intravenous cisplatin and paclitaxel infusion respectively. Both groups were treated for a period of 6 months, comparing the incidence of adverse reactions and tumor control in patients. Results The total effective rate of tumor control in trial group was significantly higher than that in control group (79.2% vs 50.0%, P <0.05), and the incidence of adverse reactions was significantly lower than that in control group (P <0.05) Reduce the severity. Conclusion Cisplatin intraperitoneal hyperthermic perfusion combined with paclitaxel intravenous chemotherapy in the treatment of advanced ovarian cancer has a significant effect and is worthy of clinical application.