目的:对血清DLL4(Delta样配体4)和VEGF(血管内皮生长因子)表达水平与食道癌的相关性进行探讨。方法:收集整理我院就诊的48例食道癌患者和48例正常健康体检者VEGF和DLL4的表达水平。结果:DLL4和VEGF在食道癌患者中阳性表达率显著高于正常健康患者(P<0.05),不同性别、年龄的患者的DLL4及VEGF阳性表达率差异不显著(P>0.05),而肿瘤分期、组织学分化、淋巴结转移情况不同的患者DLL4及VEGF阳性表达率差异显著(P<0.05)。结论:血清DLL4与VEGF水平与食道癌存在相关性,且DLL4和VEGF的表达水平与肿瘤分期,组织学分化,淋巴结转移关系密切,与性别年龄无关。 Objective: To investigate the relationship between serum DLL4 (Delta-like ligand 4) and VEGF (vascular endothelial growth factor) expression and esophageal cancer. Methods: The expression of VEGF and DLL4 in 48 patients with esophageal cancer and 48 healthy controls were collected and analyzed in our hospital. Results: The positive expression rates of DLL4 and VEGF in esophageal cancer patients were significantly higher than those in normal healthy subjects (P <0.05). There was no significant difference in the expression of DLL4 and VEGF between patients with different sex and age (P> 0.05) , Histological differentiation and lymph node metastasis in patients with different levels of DLL4 and VEGF expression was significantly different (P <0.05). Conclusion: The levels of serum DLL4 and VEGF are correlated with esophageal cancer. The expressions of DLL4 and VEGF are closely related to tumor stage, histological differentiation and lymph node metastasis, but not to sex and age.