目的:研究血浆血管内皮生长因子(vascu lar endothelial growth factor,VEGF)与食管鳞癌临床病理指标及1年内复发、转移的关系。方法:86例食管鳞癌患者根据淋巴结清扫的不同程度分为食管癌切除组和扩大淋巴结清扫组,使用ELISA法测定外周血VEGF表达。记录每位患者的临床病理指标。结果:扩大淋巴结清扫组平均清扫淋巴结组数、平均手术时间均显著高于食管癌切除组(P<0.01),两组术后并发症发生率差异无显著性(P>0.05)。食管癌切除组中血浆VEGF阳性者术后1年复发转移率均显著高于阴性者(P<0.05)。扩大淋巴结清扫组中,血浆VEGF阳性者平均转移淋巴结组数、术后1年复发转移率均高于阴性者(P<0.05)。Logistic回归分析表明,PN分期是判断术后复发转移的独立预测因子。结论:ELISA法测定血浆VEGF在判断食管癌的进展程度及复发转移等临床病理指标方面及手术方式的选择、术后辅助治疗的选择有一定参考价值。 Objective: To study the relationship between plasma vascular endothelial growth factor (VEGF) and clinicopathological parameters of esophageal squamous cell carcinoma and recurrence and metastasis within 1 year. Methods: Eighty-six patients with esophageal squamous cell carcinoma were divided into esophageal cancer resection group and expanded lymph node dissection group according to the degree of lymph node dissection. VEGF expression in peripheral blood was measured by ELISA. Record the clinical pathology of each patient. RESULTS: The mean number of lymph node dissections and mean operation time were significantly higher in the enlarged lymph node dissection group than in the esophageal cancer resection group (P<0.01). There was no significant difference in postoperative complication rates between the two groups (P>0.05). The recurrence and metastasis rate of plasma VEGF positive patients in the resection group of esophageal cancer were significantly higher than those in the negative ones (P<0.05). In the enlarged lymph node dissection group, the mean number of metastatic lymph nodes in patients with plasma VEGF positive and the rate of recurrence and metastasis at 1 year after surgery were higher than those in the negative group (P<0.05). Logistic regression analysis showed that PN staging was an independent predictor of postoperative recurrence and metastasis. Conclusion: ELISA determination of plasma VEGF has certain reference value in judging the degree of esophageal cancer progression and the clinical pathological features such as recurrence and metastasis, and the choice of surgical methods and the choice of postoperative adjuvant therapy.