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Objective To study the changes of tumor necrosis factor alpha( TNF α )and neuron specific enolase(NSE)in cerebrospinal fluid(CSF)and its clinical significance in patients with multi infarct dementia(MID).Methods The concentration of CSF TNF α was determined by RIA,and the concentration of CSF NSE was determined by ELISA in 55 patients with MID;Compared with Seventy two patients with cerebral infarction(CI)and 32 patients with functional disease of nervous system(control group).Results CSF TNF α or NSE concentration in patients with MID acute episode group was significantly higher than that in control group respectively( P