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我们测定了100例中老年腰椎间盘突出症患者推拿牵引治疗前后尿中巯基(-SH)及钾含量的变化。患者在治疗前,尿中-SH均值为776.20±33.76mmol/L,中位数(M)=515.04mmol/L;经首次治疗后,降为217.42±9.74mmol/L,M=180.92mmol/L,平均下降62%。治疗前后尿-SH含量的差别有极显著意义(P<0.01)。治疗前尿钾均值为29.92±3.0mmol/L,M=17.65mmol/L;首次治疗后降为11.49±0.96mmol/L,M=7.58mmol/L,平均下降58%。治疗前后尿钾含量的差别有极显著意义(P<0.01)。尿中两种物质下降的幅度和疗效(疼痛缓解)之间呈现明显的平行关系,疗效越理想,-SH和K~+含量的下降越明显。病情有反复时,尿中两种物质的含量也相应回升。关于-SH和疼痛之间这种关系的发现。将为疼痛的研究提供一个崭新的内容。本文对此种关系的可能机制进行了初步推测。
We measured changes in urinary thiol (-SH) and potassium levels in 100 patients with lumbar disc herniation before and after manipulation. Before treatment, the mean value of -SH in urine was 776.20 ± 33.76mmol / L and the median (M) was 515.04mmol / L. After the first treatment, the mean value of SH was 217.42 ± 9.74mmol / L and M = 180.92mmol / L , An average drop of 62%. The difference of urine-SH content before and after treatment was extremely significant (P <0.01). The average urinary potassium before treatment was 29.92 ± 3.0mmol / L, M = 17.65mmol / L; after the first treatment, it dropped to 11.49 ± 0.96mmol / L, M = 7.58mmol / L, with an average decrease of 58%. The difference of urine potassium content before and after treatment had extremely significant difference (P <0.01). There was a clear parallel between the decrease of both substances in the urine and the curative effect (pain relief). The more effective the curative effect, the more obvious the decrease of -SH and K + contents. Repeated illness, the two substances in urine also increased accordingly. The discovery of this relationship between -SH and pain. It will provide a brand new content for the study of pain. This article makes a tentative speculation on the possible mechanism of this kind of relationship.