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目的探讨2型糖尿病(T2DM)及并发症患者血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)的变化及临床意义。方法将68例T2DM患者分为单纯T2DM组(32例)和T2DM合并并发症组(36例),健康体检者30例作为正常对照组,测定各组血清Hcy、CRP并作比较。结果 T2DM并发症组血清Hcy、CRP水平高于正常对照组及单纯T2DM组,差异有统计学意义(P<0.01)。结论血清Hcy、CRP水平在T2DM及并发症组中明显升高,联合检测有助于判断其病变严重程度,为临床治疗以及判断预后提供依据。
Objective To investigate the changes and clinical significance of serum homocysteine (Hcy) and C-reactive protein (CRP) in patients with type 2 diabetes mellitus (T2DM) and complications. Methods Sixty-eight patients with T2DM were divided into three groups: T2DM group (32 cases) and T2DM group (36 cases), and 30 healthy subjects were used as normal control group. Hcy and CRP were measured and compared. Results The serum levels of Hcy and CRP in T2DM patients were significantly higher than those in normal controls and T2DM patients (P <0.01). Conclusions The levels of serum Hcy and CRP are significantly increased in T2DM and complication group. Combined detection can help determine the severity of the disease and provide the basis for clinical treatment and prognosis.