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1972年1月～1980年1月 Jude 儿童研究医院共收住急性淋巴细胞白血病(ALL)患儿616例,有422例用左旋门冬酰胺酶(L-Asp)与强的松(P)进行诱导治疗,其中421例为本文分析对象。每例均于 ALL 诊断前及每次用 L-Asp 前测定空腹与进食后之血糖浓度;各例在诊断时都测尿糖,诱导缓解期间则至少每周复查1次。患儿按总体方案Ⅶ～X,分成三组,诱导时均使用 L-Asp、P 及长春新碱,三组所用剂量相同。三组之差别仅为 L-Asp 的使用时间,在方案Ⅷ为
From January 1972 to January 1980, Jude Children’s Research Hospital received a total of 616 children with acute lymphoblastic leukemia (ALL), and 422 patients were treated with L-Asp and prednisone (P). Induction therapy, of which 421 cases were analyzed in this article. In each case, the fasting and postprandial blood glucose concentrations were measured before ALL diagnosis and before each L-Asp; each case measured urine glucose at the time of diagnosis and at least once a week during the induction period. The children were divided into three groups according to the general protocol VII-X. L-Asp, P, and vincristine were all used during induction. The doses used in the three groups were the same. The difference between the three groups is only the use time of L-Asp. In scenario VIII,