论文部分内容阅读
目的了解P53和Ki67在胃癌中的表达形式及其临床意义。方法采用免疫组化PV-9000法检查60例患者胃癌组织中P53和Ki67蛋白的表达。结果 P53和Ki67能表达蛋白组织核细胞的特征。60例患者胃癌组织中P53和Ki67蛋白表达阳性率分别为31.67%、68.33%;21例慢性胃炎患者组织中P53和Ki67蛋白表达阳性率为4.77%、38.10%。P53的蛋白组织临床分期、浸润深度、淋巴转移三项阳性表达比较差异有统计学意义(P<0.05),分化程度比较差异未见统计学意义(P>0.05);Ki67蛋白表达的临床分期、浸润深度比较差异有统计学意义(P<0.05),淋巴结转移与分化程度比较差异未见统计学意义(P>0.05)。P53和Ki67在胃癌组织中表达呈显著相关性。结论应用P53和Ki67表达形式的检查结果,可作为胃癌的诊断及预后恢复情况的重要依据。
Objective To understand the expression of P53 and Ki67 in gastric cancer and its clinical significance. Methods The expressions of P53 and Ki67 in 60 cases of gastric cancer tissues were examined by immunohistochemistry PV-9000. Results P53 and Ki67 could express the characteristics of protein nuclear. The positive rates of P53 and Ki67 in gastric cancer tissues were 31.67% and 68.33% respectively in 60 cases. The positive rates of P53 and Ki67 in tissues of 21 cases with chronic gastritis were 4.77% and 38.10% respectively. There were significant differences in the clinical stage, depth of invasion and lymph node metastasis of P53 (P <0.05), but there was no significant difference in differentiation (P> 0.05). The clinical stage of Ki67 protein expression, The depth of invasion was significantly different (P <0.05). There was no significant difference in lymph node metastasis and differentiation (P> 0.05). P53 and Ki67 expression in gastric cancer was significantly correlated. Conclusion The results of the examination of the expressions of P53 and Ki67 can be used as an important basis for the diagnosis and prognosis of gastric cancer.