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70年代发现的下丘脑多肽系统使人们认识到,下丘脑对内环境稳定的调节涉及这些肽类神经递质和单胺类神经递质的精密平衡。本文复习肽类及单胺类神经递质对胃酸分泌调节的研究进展,并试图将其与有关胃酸分泌的解剖学研究结合起来。胃酸分泌的神经解剖通路损害或刺激中枢神经系统对胃酸分泌有影响。许多研究证明,电刺激下丘脑腹侧内部降低胃酸分泌,刺激下丘脑侧区增加胃酸分泌,迷走神经切除可消除后者。Colin-Jones和Hisnsworth发现,下丘脑侧区注射α-脱氧葡萄糖引起胃酸分泌增加,若先作迷走神经切断则不发生此作用。局部麻醉下丘脑侧区可抑制
Hypothalamic polypeptide systems discovered in the 1970s have led to the recognition that the hypothalamus’s regulation of the homeostasis involves the precise balance of these peptide neurotransmitters with monoamine neurotransmitters. This review of peptides and monoamine neurotransmitters on the regulation of gastric acid secretion research, and trying to combine with the relevant gastric acid secretion of anatomical research. Gastric acid secretion of the nerve anatomical pathways damage or stimulate the central nervous system on gastric acid secretion. Many studies have shown that electrical stimulation of the hypothalamus inside the stomach to reduce gastric acid secretion, stimulation of the hypothalamic area to increase gastric acid secretion, vagotomy can eliminate the latter. Colin-Jones and Hisnsworth found that injection of a-deoxyglucose into the lateral hypothalamus causes increased gastric acid secretion, which does not occur if vaginal nerve is cut first. Local anesthesia hypothalamic area can be inhibited