目的了解2008~2013年泰安市手足口病流行病学特征。方法应用描述性流行病学方法对泰安市2008~2013年手足口病疫情资料进行分析。结果 2008~2013年泰安市累计报告手足口病39 497例,死亡5例,年均发病率为118.30/10万,平均死亡率为0.015/10万,病死率为0.013% ;发病呈周期性流行趋势。手足口病每年5~8月发病较多,个别年份10~12月可再次发生流行,并可使次年手足口病流行提前;经济较发达及沿交通干线分布的区域为手足口病的高发地区(P<0.01);手足口病发病以散居儿童为主,占全部报告病例的72.70% ,1~3岁发病率最高,报告病例占全部报告病例的69.68% ;发病至诊断时间间隔2d及以上者占35.06% ;2008、2009、2011年以EV71为优势流行毒株,2010年、2012、2013年以CA16为优势流行株。结论HFMD发病呈周期性流行趋势,秋冬流行峰的出现预示来年HFMD流行将提前,EV71与CA16交替流行使HFMD疫情居高不下。 Objective To understand the epidemiological characteristics of HFMD in Tai’an from 2008 to 2013. Methods Descriptive epidemiological methods were used to analyze the data of HFMD in Tai’an from 2008 to 2013. Results A total of 39 497 HFMD cases and 5 deaths were reported in Tai’an City from 2008 to 2013, with an average annual incidence rate of 118.30 / lakh and an average mortality rate of 0.015 / lakh and a case fatality rate of 0.013%. The incidence was cyclical trend. Hand-foot-mouth disease occurs more frequently from May to August every year, and the epidemic may occur again from October to December in individual years, and the epidemic of hand-foot-mouth disease can be advanced in the next year. The areas with more developed economy and distribution along the main arterial line are high incidence of hand-foot-mouth disease (P <0.01). The incidence of hand-foot-mouth disease was mainly in scattered children, accounting for 72.70% of the total reported cases, with the highest incidence in 1-3 years. The reported cases accounted for 69.68% of the total reported cases. The onset to diagnosis interval was 2 days and Accounting for 35.06%; EV71 was the dominant strain in 2008, 2009 and 2011, and CA16 was the predominant strain in 2010, 2012 and 2013; Conclusions The incidence of HFMD presents a cyclical trend. The occurrence of the peak of autumn and winter indicates that the epidemic of HFMD will advance ahead of schedule. The epidemic of HFMD will be high with the alternation of EV71 and CA16.