作为一种强大的T细胞激活剂,超抗原具有激活T细胞杀伤HLA-DR+肿瘤细胞的能力,但这种杀伤作用无特异性。抗体靶向超抗原通过抗肿瘤抗体与超抗原偶联,既具有超抗原活性,又具有肿瘤靶向性,从而可以选择性地结合到目标细胞,进行有效的特异性杀伤,因此,抗体靶向超抗原在肿瘤的生物治疗领域具有广泛的应用前景。 As a potent T cell activator, superantigens have the ability to activate T cells to kill HLA-DR + tumor cells, but this killing effect is nonspecific. Antibody-targeted superantigens, coupled with superantigens by anti-tumor antibodies, have both superantigen and tumor-targeting properties that allow them to selectively bind to target cells for efficient and specific killing. Thus, antibody targeting Superantigen has a wide range of applications in the field of biological treatment of tumors.