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目的：探讨环氧合酶-2（COX-2）基因-1195 G>A多态性位点与缺血性脑卒中（IS）患者阿司匹林抵抗（AR）的相关性。方法：纳入中国北方汉族IS患者210例，根据血小板聚集率分为阿司匹林敏感（AS）组147例，非AS组63例。采用扩增阻碍突变系统（ARMS）结合TaqMan探针的实时荧光定量PCR方法检测-1195 G>A多态性。结果：-1195G>A位点基因型、显性模型分布频率在AS组及非AS组中差异均无统计学意义（＞0.05）；非AS组中-1195G>A位点（GA+AA）基因型频率及A等位基因频率高于AS组，差异均有统计学意义（x2=4.96，=0.03；x2=5.50，=0.02）；多因素分析提示，与GG基因型相比，COX-2的-1195G>A位点（GA+AA）基因型发生AR可能性更大（=2.41，“,”ObjectiveTo study the correlation between single nucleotide polymorphisms (SNPs) of-1195G>A of cyclooxygenase-2 (COX-2) gene and Aspirin resistance (AR) in patients with ischemic stroke (IS). Methods:According to the rate of platelet aggregation, 210 northern Chinese Han patients with IS were divided into Aspirin sensitivity (AS) group (147 cases) and non-Asgroup [17 AR cases, and 46 Aspirin semi-resistance (ASR) cases] (n=63). The SNPs were detected by Amplification mutation system (ARMS) combined with TaqMan probe in a real-time PCR. Results:There were no significant differences in the genotype, allele, additive or recessive model frequencies of-1195G>A polymorphisms between the 2 groups. The significant difference between (GA+AA) and GG genotype frequencies of-1195G>A polymorphisms were observed in groups of AS and non-AS ( =0.03). For A allele of-1195G>A, there was also a significant difference between the two groups ( =0.02). On multivariate analysis controlling for conventional vascular risk factors, the-1195 GA and AA genotypes were identified inde-pendently to be related with (ASR+AR) ( =2.41,:1.07~5.42, =0.03). Conclusion:-1195G>A poly-morphism of COX-2 gene was associated with AR or ASR in patients with IS, which may be a genetic predisposi-tion to phenotypes of AR or ASR.