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饰胶蛋白聚糖(decorin,DCN)是一种小分子蛋白聚糖,广泛存在于细胞外基质中,富含亮氨酸,因其能够修饰胶原原纤维而得名。近年来对DCN抑制器官纤维化、抗肿瘤生长及其他生理作用等研究,尤其是可能的作用机制方面均取得了重大的进展。
Decorin (DCN) is a small molecule proteoglycan that is found extensively in the extracellular matrix and is rich in leucine because of its ability to modify collagen fibrils. In recent years, DCN has made great progress in inhibiting the organ fibrosis, anti-tumor growth and other physiological effects, especially the possible mechanism of action.