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目的探讨弓形虫感染对育龄妇女生殖健康的影响。方法采用金标免疫诊断试验和酶联免疫吸附试验测定4310例育龄妇女血清弓形虫抗体IgG、IgM和循环抗原。结果4310例育龄妇女中血清弓形虫抗体或循环抗原阳性606例,阳性率14.06%,阳性组中流产、死胎、畸形发生率高于阴性组(P<0.01),妇科疾病如子宫肌瘤、宫外孕、盆腔炎、不孕症的患病率也显著高于阴性组(P<0.01)。结论育龄妇女弓形虫感染与异常妊娠结局及某些妇科疾病密切相关,加强对育龄妇女弓形虫血清学监测和健康教育具有十分重要的意义。
Objective To investigate the effects of Toxoplasma gondii infection on reproductive health of women of childbearing age. Methods IgG, IgM and circulating antigens of serum toxoplasma gondii in 4310 women of childbearing age were measured by gold standard immunodiagnosis test and enzyme-linked immunosorbent assay. Results Among the 4310 women of childbearing age, there were 606 positive cases of Toxoplasma gondii antibody or circulating antigen, the positive rate was 14.06%. The incidence of miscarriage, stillbirth and fetus in the positive group was higher than that in the negative group (P <0.01). Gynecological diseases such as uterine fibroids, ectopic pregnancy , Pelvic inflammatory disease, the prevalence of infertility was also significantly higher than the negative group (P <0.01). Conclusion Toxoplasma infection in women of childbearing age is closely related to the outcome of abnormal pregnancy and some gynecological diseases. It is of great significance to strengthen the serological surveillance and health education of Toxoplasma gondii in women of childbearing age.