基因治疗是指利用DNA重组和基因转移技术在基因水平对疾病进行治疗的一类方法 ,基因治疗在眼科有广阔的应用前景 ,增生性玻璃体视网膜病变是视网膜脱离手术的主要并发症和手术失败的主要原因 ,常导致严重的视力损害。本文就增生性玻璃体视网膜病变 (PVR)基因治疗的途径、方法、目前进行的实验研究、存在问题及前景展望作一综述。 Gene therapy refers to the use of DNA recombination and gene transfer technology at the genetic level of disease treatment of a class of methods, gene therapy has broad application prospects in ophthalmology, proliferative vitreoretinopathy is the main complications of retinal detachment surgery and surgical failure The main reason, often leads to serious vision damage. This review summarizes the ways and methods of gene therapy of proliferative vitreoretinopathy (PVR), the current experimental research, existing problems and prospects.