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目的:探讨真菌在慢性鼻窦炎、鼻息肉患者中的致病作用。方法:采用PCR方法分别检测66例慢性鼻窦炎患者(鼻窦炎组)生理盐水冲洗前、后的鼻息肉及鼻窦黏膜的真菌,同时检测21例正常志愿者(对照组)的鼻腔分泌物中的真菌,应用χ2检验比较其差异性。结果:鼻息肉组真菌阳性率:息肉为89.2%,黏膜为89.4%,分别与对照组(66.7%)比较,差异均有统计学意义(均P<0.05);用生理盐水冲洗后,鼻息肉组真菌阳性率:息肉为7.14%,黏膜为2.63%,分别与冲洗前比较,差异均有统计学意义(均P<0.05)。结论:真菌在鼻息肉和鼻窦炎的发病中可能发挥重要作用,PCR技术在真菌检测中有重要意义。
Objective: To explore the pathogenic role of fungi in patients with chronic sinusitis and nasal polyps. Methods: PCR was used to detect the nasal polyps and sinus mucosa of 66 chronic sinusitis patients (sinusitis group) before and after the saline flushing, respectively, and the nasopharyngeal secretions of 21 normal volunteers (control group) Fungi, χ2 test using the difference compared. Results: The positive rates of fungi in nasal polyps group were 89.2% for polyps and 89.4% for mucosa, respectively (all P <0.05) compared with control group (66.7%). After washing with saline, nasal polyps Group Fungal positive rate: polyps 7.14%, mucosa was 2.63%, respectively, compared with before washing, the difference was statistically significant (P <0.05). Conclusion: Fungi may play an important role in the pathogenesis of nasal polyps and sinusitis. PCR is of great significance in the detection of fungi.