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目的:对比分析用四联疗法和三联疗法对确诊为幽门螺旋杆菌胃炎患者实施治疗的临床效果。方法:随机选取2009年1月~2014年1月,80位通过碳14尿素呼气试验检测,确诊感染幽门螺旋杆菌的胃炎患者。随机分为观察组和对照组,每组40例。观察组患者使用左氧氟沙星、阿莫西林克拉维酸钾、兰索拉唑、胶体果胶铋四联疗法进行治疗,对照组使用甲硝唑、阿莫西林克拉维酸钾、兰索拉唑三联疗法进行治疗,治疗时间都为十四天,对比两组对幽门螺旋杆菌的根除率。结果:四联疗法的根除率为90%,三联疗法的根除率为62%。观察组幽门螺旋杆菌的根除率明显高于对照组,统计学比较有显著差异(P<0.05)。结论:四联疗法较三联疗法杀灭胃幽门螺旋杆菌更有效,可作为临床杀灭幽门螺旋杆菌的优选方法。
Objective: To compare and analyze the clinical effect of quadruple therapy and triple therapy in the treatment of patients diagnosed as Helicobacter pylori gastritis. Methods: From January 2009 to January 2014, 80 patients with gastritis infected with Helicobacter pylori were diagnosed by detecting carbon 14 urea breath test. Randomly divided into observation group and control group, 40 cases in each group. Patients in the observation group were treated with levofloxacin, amoxicillin and clavulanate potassium, lansoprazole and colloidal pectin bismuth quadruple therapy. Patients in the control group were treated with metronidazole, amoxicillin and clavulanic acid, and triple therapy with lansoprazole For treatment, treatment time is fourteen days, compared to two groups of H. pylori eradication rate. Results: The quadruple therapy achieved an eradication rate of 90% and the triple therapy achieved an eradication rate of 62%. The eradication rate of Helicobacter pylori in the observation group was significantly higher than that in the control group, with statistical significance (P <0.05). Conclusion: The quadruple therapy is more effective than the triple therapy in killing H. pylori and can be used as the preferred method to kill H. pylori clinically.