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目的探讨血管紧张素转换酶抑制剂(ACEI)联合Ca2+通道阻滞剂(CCB)治疗糖尿病合并高血压病的疗效。方法回顾分析2007-07-2009-06间新疆武警兵团指挥部后勤部医院收治糖尿病合并高血压病患者90例。患者随机分入三组:苯那普利组、氨氯地平组及联合治疗组,每组各30例。苯那普利组口服苯那普利10mg,1次/d;氨氯地平组口服氨氯地平5 mg,1次/d;联合治疗组口服苯那普利10 mg、氨氯地平5 mg,1次/d;均治疗8周。治疗前及治疗过程中测血压及尿白蛋白排泄率(UAER)。结果苯那普利组、氨氯地平组及联合治疗组降压总有效率分别为83.3%、80%和93.3%,联合治疗组降压效果明显优于苯那普利组和氨氯地平组(P<0.05)。治疗8周后苯那普利组和联合治疗组UAER较治疗前明显下降(P<0.05)。结论苯那普利联合氨氯地平治疗糖尿病合并高血压病的疗效好,不良反应少,值得在临床推广。
Objective To investigate the efficacy of angiotensin converting enzyme inhibitor (ACEI) combined with Ca2 + channel blocker (CCB) in the treatment of diabetes complicated with hypertension. Methods A retrospective analysis of 90 cases of patients with diabetes mellitus and hypertension in the Logistics Department Hospital of Xinjiang Armed Police Corps Command Center between July 2007 and September 2009 was conducted. Patients were randomly divided into three groups: benazepril group, amlodipine group and combination therapy group, 30 cases in each group. The benazepril group was treated with benazepril 10mg once a day, the amlodipine group was given amlodipine 5 mg once a day, and the combination therapy group was treated with benazepril 10 mg, amlodipine 5 mg, 1 times / d; were treated for 8 weeks. Blood pressure and urinary albumin excretion rate (UAER) before and during treatment. Results The total effective rate of benazapril, amlodipine and combination therapy were 83.3%, 80% and 93.3%, respectively. The antihypertensive effect of combination group was better than those of benazepril and amlodipine (P <0.05). UAER in benazepril group and combination group decreased significantly (P <0.05) 8 weeks after treatment. Conclusion benazepril combined with amlodipine in the treatment of diabetic patients with hypertension has good curative effect and less adverse reactions, which is worthy of clinical promotion.