慢性移植肾肾病(CAN)是移植肾远期肾功能衰竭最主要的原因,肾间质纤维化是CAN的主要病理变化之一。诊断慢性移植肾间质纤维化的方法分为病理学、分子生物学及物理学方法,治疗方法主要包括免疫抑制药物、物理治疗、植物提取药物治疗和干细胞治疗等。目前其诊断及治疗方法均有待进一步的临床研究。 Chronic allograft nephropathy (CAN) is the leading cause of long-term renal failure in renal allografts. Renal interstitial fibrosis is one of the major pathological changes in CAN. Diagnosis of chronic renal interstitial fibrosis method is divided into pathology, molecular biology and physical methods, treatment methods include immunosuppressive drugs, physical therapy, plant extract drug treatment and stem cell therapy. At present, its diagnosis and treatment are subject to further clinical studies.