L eber遗传性视神经病 (L eber′s hereditary optic neuropa-thy,L HON)是一种多累及青年人常常致盲的遗传性视神经异常 ,分子遗传学研究表明多种线粒体 DNA(mitochondrialDNA,mt DNA)突变是 L HON明显的病因。但是 mt DNA的缺陷不是唯一的决定因素 ,因为带有这一特异性病症的 L eber hereditary optic neuropathy (L HON) is a hereditary optic nerve abnormality that frequently affects young people and often leads to blindness. Molecular genetic studies have shown that various mitochondrial DNA (mt DNA ) Mutation is a clear cause of L HON. But the defect of mt DNA is not the only determinant, because with this specific disorder