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目的:综述超临界流体沉淀技术的研究现状。方法:介绍超临界流体快速膨胀溶液过程、气体抗溶剂过程、超临界流体抗溶剂过程、气溶胶溶剂萃取系统、超临界流体强化溶液快速分散技术、气体饱和溶液沉析等SFP技术的原理、特点及其在药学中的应用。结果:通过控制压力和温度等参数,就可以实现气相或液相重结晶,而得到大小分布均匀的微细颗粒。结论:超临界流体沉淀技术以其特有的优点成为具有广阔应用前景的超细微粒制备方法。
Objective: To summarize the research status of supercritical fluid deposition. Methods: The principles and characteristics of SFP technology, such as the process of rapid expansion of supercritical fluid, gas-solvent process, anti-solvent process of supercritical fluid, aerosol solvent extraction system, rapid dispersion of supercritical fluid enhanced solution and gas saturated solution precipitation And its application in pharmacy. Results: By controlling parameters such as pressure and temperature, gas phase or liquid phase recrystallization can be achieved to obtain fine particles with uniform size distribution. Conclusion: Supercritical fluid precipitation technology has become a promising method for the preparation of ultrafine particles with its unique advantages.