论文部分内容阅读
分析EB病毒核抗原1-IgA抗体(EBNA1-IgA)的不同状态及变化趋势,并探讨人群的鼻咽癌发病风险。检测中山市小榄镇2009~2010年入组的16 695位30~59岁参加鼻咽癌筛查人群血清,按首次筛查和随访中EBNA1/IgA抗体状态将筛查人群进行分组,对照组为未参加筛查的两个镇区同年龄组人群,利用中山市肿瘤登记系统、死因登记系统随访至2014年12月31日,分析各组人群的鼻咽癌发病风险。与对照组相比,基线抗体阴性人群的发病风险比为0.46(95%CI 0.25~0.86),基线抗体阳性人群的发病风险比为31.1(95%CI 21.0~46.1);复查人群中上升组、持续阳性组的发病风险比分别为82.4(95%CI 36.1~188.2),26.4(95%CI 12.3~52.5),而下降组和波动组中未见病例。EBNA1/IgA基线阳性人群在5年中有很高的发病风险,复查人群中上升组和持续阳性组也有很高的发病风险,下降组和波动组发病风险较低。
To analyze the different status and change trend of Epstein-Barr virus nuclear antigen 1-IgA antibody (EBNA1-IgA) and to explore the population risk of nasopharyngeal carcinoma. To detect the serum levels of 16 695 patients aged 30-59 years who participated in NPC screening from 2009 to 2010 in Xiaolan Town, Zhongshan City. According to the EBNA1 / IgA antibody status in the first screening and follow-up, the screening population was divided into control group The two towns in the same age group, which did not participate in the screening, were enrolled in Zhongshan Cancer Registration System. The cause of death registration system was followed up until Dec. 31, 2014 to analyze the incidence of NPC. Compared with the control group, the risk ratio of baseline antibody-negative population was 0.46 (95% CI 0.25-0.86), and the risk of baseline antibody-positive population was 31.1 (95% CI 21.0-46.1); in the ascending group, The incidence of risk of persistent positive group were 82.4 (95% CI 36.1 ~ 188.2), 26.4 (95% CI 12.3 ~ 52.5), while there were no cases in descending group and fluctuating group. The baseline EBNA1 / IgA positive population had a high risk of developing disease at 5 years. The elevated risk and persistent positive rates in the repeat population were also associated with a high risk of morbidity, with a lower risk of decline in the declining and fluctuating groups.