水通道蛋白4(AQP-4)是脑组织内高表达的一种水通道蛋白,主要表达于星形胶质细胞和室管膜细胞,尤其在与毛细血管和软脑膜直接接触的星形胶质细胞表达丰富,是参与脑水肿形成的重要分子,在水分子快速跨膜转运中发挥重要作用。最近研究表明,AQP-4在创伤性脑水肿的病理生理变化中发挥重要的作用。深入研究AQP-4与创伤性脑水肿之间的关系,将可能为临床治疗脑水肿提供新的思路和途径。 Aquaporin 4 (AQP-4) is a type of aquaporin that is highly expressed in brain tissue and is expressed mainly in astrocytes and ependymal cells, especially in astrocytes that are in direct contact with the capillaries and the pia mater Cells are abundant in expression and are important molecules involved in the formation of brain edema. They play an important role in the rapid transmembrane transport of water molecules. Recent studies have shown that AQP-4 plays an important role in the pathophysiological changes of traumatic brain edema. In-depth study of the relationship between AQP-4 and traumatic brain edema may provide new ideas and ways for the clinical treatment of cerebral edema.