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目的探讨艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人的肝脏功能损害情况及其影响因素。方法回顾分析179例HIV/AIDS病人临床资料,根据肝脏功能损害程度,分为肝功能正常组、肝功能轻度损害组、中度损害组、重度损害组,比较各组间相关情况。结果肝功能损害组使用肝毒性药物、合并HBV和/或HCV感染的比例均高于肝功能正常组,两者比较差异有显著的统计学意义(P值分别为0.039、0.030、0.003)。中重度肝功能损害组使用肝毒性药物的比例高于轻度损害组,两者比较差异有显著的统计学意义(P=0.037)。结论HIV/AIDS病人肝脏损害发生率高,而男性、使用肝损害药物、合并HBV和/或HCV是HIV/AIDS病人发生肝脏损害的危险因素。
Objective To investigate the hepatic dysfunction and its influencing factors in patients with HIV / AIDS. Methods A retrospective analysis of 179 cases of HIV / AIDS patients clinical data, according to the extent of liver dysfunction, divided into normal liver function group, mild dysfunction group, moderate damage group, severe injury group, the comparison between the various groups. Results The percentage of patients with hepatic dysfunction in using hepatotoxic drugs and HBV and / or HCV infection was significantly higher than that in patients with normal liver function (P = 0.039,0.030, 0.003, respectively). The rate of using hepatotoxic drugs in patients with moderate-severe liver dysfunction was higher than that in patients with mild impairment, the difference was statistically significant (P = 0.037). Conclusions The incidence of liver damage in HIV / AIDS patients is high, while in men, the use of hepatic impairment drugs, combined with HBV and / or HCV is a risk factor for liver damage in HIV / AIDS patients.