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目的探讨持续性房颤应用华法林预防脑栓塞的疗效。方法 96例持续性房颤患者分为华法林组58例,对照组38例,根据INR调整华法林剂量,随访3年。结果华法林组脑栓塞发生率明显低于对照组,出血率高于对照组。结论华法林可降低持续性房颤患者脑栓塞发生率,但增加出血风险。
Objective To investigate the efficacy of warfarin in prevention of cerebral embolism in patients with persistent atrial fibrillation. Methods A total of 96 patients with persistent AF were divided into 58 patients in warfarin group and 38 patients in control group. Warfarin dose was adjusted according to INR and followed up for 3 years. Results The incidence of cerebral embolism in warfarin group was significantly lower than that in control group, and the bleeding rate was higher than that in control group. Conclusion Warfarin can reduce the incidence of cerebral embolism in patients with persistent AF but increase the risk of bleeding.