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目的 探讨黄芪多糖（APS）作为重组（CHO细胞）乙肝疫苗免疫佐剂的可行性。方法APS与重组（CHO细胞）乙肝病毒表面抗原（HBsAg）混合制成疫苗,进行了动物毒性试验、过敏试验及效力试验。结果 该佐剂毒性轻微,无过敏反应,同一剂量组动物血清抗-HBs阳转率高于Al（OH）3对照组。结论APS是一种很有潜力的疫苗佐剂。
Objective To investigate the feasibility of using astragalus polysaccharide (APS) as adjuvant for recombinant (CHO cell) hepatitis B vaccine. Methods APS and recombinant (CHO cells) hepatitis B virus surface antigen (HBsAg) were mixed into a vaccine, animal toxicity test, allergy test and efficacy test. Results The adjuvant had mild toxicity and no allergic reaction. The positive rate of anti-HBs in serum of the same dose group was higher than that of Al (OH) 3 control group. Conclusion APS is a promising vaccine adjuvant.