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本文利用Ｌｅｗｉｓ肺癌自发肺转移模型研究了７５ｍＧｙＸ线全身照射对小鼠Ｌｅｗｉｓ肺癌（ＬＬｃ）生长及自发转移的影响。结果显示，小鼠在足掌注射瘤细胞后一周，原发瘤生瘤率在照后搔种细胞组比对照组低（Ｐ＜０．０５）；原发瘤重量铰对照组轻（Ｐ＜０．０１）；肺转移瘤结节数无论是照后接种细胞组还是接种细胞后照射组均较对照组显著减少（Ｐ＜０．，１）；肺转移率也明显降低（Ｐ＜０．０１），表明小剂量照射有抑制ＬＬＣ生长及自发性肺转移作用；免疫学参数测定证明。小鼠在７５ｍＧｙ照射后２４小时免疫功能有所增强，提示照后免疫功能增强是小剂量照射抑制ＬＬＣ生长及自发肺转移的可能机理之一。
In this study, Lewis lung cancer spontaneous lung metastasis model was used to study the effect of 75mGyX whole body irradiation on the growth and spontaneous metastasis of Lewis lung cancer (LLc) in mice. The results showed that one week after the injection of tumor cells into the paw of the mice, the tumorigenicity rate of the primary tumors was lower in the seed cells after irradiation than in the control group (P<0.05); the weight of the primary tumors in the control group was light (P< 0.01); pulmonary metastasis nodules no matter whether it is inoculated after irradiation group or inoculated cells after irradiation group compared with the control group was significantly reduced (P <0., 1); lung metastasis rate was also significantly reduced (P <0. 01) shows that low-dose irradiation can inhibit the growth of LLC and spontaneous pulmonary metastasis; immunological parameter test proved. Immune function was enhanced 24 h after 75 mGy irradiation in mice, suggesting that enhancement of immune function after irradiation is one of the possible mechanisms of low dose radiation inhibition of LLC growth and spontaneous lung metastasis.