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依据Ｔ细胞活化的双信号学说[1],利用免疫基因修饰肿瘤细胞,使其更具有免疫原性和抗原呈递细胞的功能,是肿瘤疫苗设计的重要策略之一。近年的研究发现,共刺激分子ＣＤ80和ＣＤ86在诱发Ｔ细胞介导的抗肿瘤免疫方面起着重要的共刺激作用,在鼠的体内外试验以及人的体外试验中...
According to the dual signal theory of T cell activation [1], the use of immune genes to modify tumor cells to make them more immunogenic and antigen-presenting cell functions is one of the important strategies for tumor vaccine design. Recent studies have found that co-stimulatory molecules CD80 and CD86 play an important costimulatory role in inducing T cell-mediated anti-tumor immunity in vivo in vitro and in vivo in humans.