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目的 :探讨高原汽车兵重复急性低氧应激过程中脂质代谢和体液免疫反应的变化 ;方法 :对担负喀喇昆仑山运输任务的某汽车部队 2 8名驾驶员 ,在完成全年高原运输任务前 (海拔 14 0 0m处 )、全年任务完成一半时 (上高原 4次～ 6次 ,海拔 3 70 0m处 )及完成全年运输任务后一个月 (海拔 14 0 0m)检测其血清胆固醇 (Ch)、甘油三酯 (TG)、高密度脂蛋白 (HDL -C)、低密度脂蛋白 (LDL -C)、载脂蛋白A -1、B(ApoA -1、B)、免疫球蛋白(IgA、IgG、IgM)、补体 (C3、C4)和C -反应蛋白 (CRP)的浓度 ;结果 :完成全年高原运输任务中较前和后血清Ch、TG、ApoA -1、IgG、IgM、C3、C4、CRP增高有显著性 (P <0 .0 5或P <0 .0 1) ,LDL -C在完成全年高原运输任务中较前降低显著 (P <0 .0 5 ) ,前较后变化无统计学差异 (P >0 .0 5 ) ;结论 :高原低氧引起脂质代谢紊乱 ,影响免疫功能 ,并激活补体 ,造成免疫损伤 ,重复急性低氧应激停止后 ,机体脂质代谢和免疫反应相对得到恢复。
OBJECTIVE: To investigate the changes of lipid metabolism and humoral immune response during repeated acute hypoxia stress in plateau motor vehicle. Methods: A total of 28 motorists from a certain car unit carrying Karakoram mountain transport were enrolled in the study. Before the mission (1400 meters above sea level), the serum cholesterol level was measured at halfway through the year (4 times to 6 times on the plateau and 3 070 m above sea level) and one month after completing the annual transport mission (1400 meters above sea level) (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), apolipoprotein A -1, B (ApoA -1, B), immunoglobulin Serum levels of ChA, TG, ApoA-1, IgG and IgM were measured before and after the plateau transport task was completed in the whole year (IgA, IgG, IgM), complement (C3, C4) and C-reactive protein (CRP) (P <0.05 or P <0.01). The LDL-C decreased significantly (P <0. 05) in completing the annual plateau transport task, There was no significant difference between the two groups (P> 0.05) .Conclusion: High altitude hypoxia can cause disorder of lipid metabolism, affect immune function, activate complement, cause immune damage and repeat acute hypoxia After the cessation of stress, the body’s lipid metabolism and immune response are relatively restored.