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目的:观察联合长春瑞滨对兔VX2肿瘤组织皮下移植瘤模型的干预作用,并探讨肿瘤发生时氧化与抗氧化失衡的相互关系。方法:采用兔VX2肿瘤组织悬液种植法制备皮下移植瘤模型随机分为对照组(a)、长春瑞滨组(b)、草苁蓉联合长春瑞滨干预组(c)分别给与相应药物。结果:第2周开始用长春瑞滨干预后,B组实验兔皮下移植瘤生长率较A组降低,P<0.05;C组瘤体生长率较B组降低,P<0.05,较A组明显降低P<0.01。第3周应用长春瑞滨第2次干预后,B组及C组实验动物的皮下移植瘤生长率均较A组明显降低,P<0.01;C组实验动物的皮下移植瘤生长率低于B组,但差异不显著,P>0.05。3.过氧化氢酶含量B组与A组比较明显升高,有显著性差异P<0.001,C组不仅比A组有显著性差异P<0.001,而且比B组也有显著性差异P<0.01。结论:(1)草苁蓉与长春瑞滨联合应用,协同抑制兔VX2肿瘤组织皮下移植瘤生长的作用。(2)长春瑞滨联合草苁蓉可以改善实验动物体内的氧化-抗氧化失衡现象。
OBJECTIVE: To observe the intervention of vinorelbine on the subcutaneously transplanted tumor model of VX2 tumor in rabbits and to explore the relationship between the oxidative and anti-oxidative imbalance in tumorigenesis. Methods: The subcutaneous xenograft model of rabbit VX2 tumor tissue suspension was randomly divided into control group (a), vinorelbine group (b), Cistanche tuberculosis combined vinorelbine intervention group (c) . Results: After the intervention of vinorelbine from the second week, the growth rate of subcutaneous xenografts in experimental group B was lower than that in group A (P <0.05), and the growth rate in group C was lower than that in group B (P <0.05) Reduce P <0.01. After the second intervention with vinorelbine in the third week, the growth rate of subcutaneous xenografts in experimental animals in groups B and C was significantly lower than that in group A (P <0.01). The growth rate of subcutaneous xenografts in experimental animals in group C was lower than that in group B Group B, but the difference was not significant, P> 0.05.3. The catalase content in group B was significantly higher than that in group A (P <0.001), C group not only had significant difference (P <0.001) But also significantly different from group B (P <0.01). Conclusion: (1) Cistanche tuberculosis combined with vinorelbine synergistically inhibit the growth of subcutaneously transplanted tumors in rabbit VX2 tumor tissue. (2) Vinorelbine combined with Cistanche can improve the oxidation-antioxidant imbalance in experimental animals.