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目的 探讨血清胆红素浓度变化对脂质过氧化物及脑梗死的影响。方法 检测 5 8例脑梗死 (CI)患者血清胆红素 (BIL)、氧化修饰低密度脂蛋白 (ox- L DL)、丙二醛 (MDA)浓度 ,并与 32例健康者进行比较。结果 脑梗死组血清总胆红素 (TBIL)、间接胆红素 (IBIL)和直接胆红素 (DBIL)较正常对照组显著降低 (P<0 .0 1,P<0 .0 5 ) ,而 ox- L DL、MDA较正常对照组显著增高 (P<0 .0 1)。直线相关分析显示 :IBIL与 MDA、ox- L DL呈显著负相关 (r1 =- 0 .32 94 ,P<0 .0 5 ;r2 =- 0 .390 5 ,P<0 .0 1)。结论 血清胆红素浓度降低可导致 ox- L DL增多 ,通过氧化损伤、内源性 CO减少等机制 ,促进动脉粥样硬化 (As)、血栓形成和脑梗死的发生发展。低血清胆红素可能是脑梗死的一个新的危险因素。
Objective To investigate the effect of serum bilirubin concentration on lipid peroxides and cerebral infarction. Methods Serum bilirubin (BIL), ox-LDL and malondialdehyde (MDA) in 58 cases of cerebral infarction were detected and compared with 32 healthy controls. Results Serum total bilirubin (TBIL), indirect bilirubin (IBIL) and direct bilirubin (DBIL) in cerebral infarction group were significantly lower than those in normal control group (P <0.01, P <0.05) However, ox-LDL and MDA were significantly higher than those in normal control group (P <0.01). Linear correlation analysis showed that there was a significant negative correlation between IBIL and MDA and oxLDL (r1 = - 0.3294, P <0.05; r2 = -0.3905, P <0.01). Conclusions The decrease of serum bilirubin concentration leads to the increase of ox-L-DL. It promotes the development of atherosclerosis (As), thrombosis and cerebral infarction through mechanisms of oxidative damage and endogenous CO reduction. Low serum bilirubin may be a new risk factor for cerebral infarction.