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目的 合成一种前药白藜芦醇烟酸酯。方法 在金属锂片和催化量的萘的存在下 ,3 ,5 二甲氧基苯甲醛与对甲氧基苯甲醇的三甲基硅醚反应经过一系列转变得到白藜芦醇 ,白藜芦醇与烟酰氯反应得到白藜芦醇烟酸酯。结果 设计并合成了白藜芦醇烟酸酯。结论 提供了一种合成白藜芦醇及白藜芦醇烟酸酯的方法 ,采用KHSO4 脱水可选择性的得到反式产物。
Objective To synthesize a prodrug resveratrol nicotinate. Methods The reaction of 3,5-dimethoxybenzaldehyde with trimethylsilyl p-methoxybenzyl alcohol in the presence of lithium metal and a catalytic amount of naphthalene led to a series of transformations of resveratrol, The alcohol reacts with nicotinoyl chloride to give resveratrol nicotinate. Results Resveratrol nicotinate was designed and synthesized. Conclusions A method for the synthesis of resveratrol and resveratrol nicotinate was provided. The trans-product was selectively obtained by dehydration with KHSO4.