目的 分析骨科大手术后下肢深静脉血栓形成的预防及临床护理。方法 选取2019年12月至2020年12月于大连大学附属中山医院进行骨科大手术的患者88例，将患者按照随机分配的方法分成两组，即对照组（44例）和试验组（44例），对照组患者给予普通护理，试验组患者采用临床综合护理，对比两组患者护理后的效果。结果 对照组患者进行护理后出现深静脉血栓的患者有17例（38.64%），试验组患者进行临床综合护理后出现深静脉血栓的患者有2例（4.54%），差异有统计学意义（P＜0.05）。试验组患者对护理人员的工作态度、“,”Objective To analyze the prevention and clinical nursing of lower extremity thrombosis after orthopaedic major surgery. Methods A total of 88 patients who underwent major orthopedic surgery from December 2019 to December 2020 were randomly divided into two groups: control group (44 cases) and test group (44 cases). The patients in the control group were given general nursing care， the patients in the test group were given clinical comprehensive nursing care， and the effect of the two groups after nursing care was compared. Results In the control group， there were 17 patients (38.64%) with thrombosis， in the test group， there were 2 patients (4.54%) with thrombosis， the difference was statistically significant (P＜0.05). Patients in the experimental group are better than the control group in terms of their satisfaction with nursing staff\'s work attitude， management， communication and ability. The patients in the test group had a satisfactory score of (98.65±4.21)， the nursing satisfaction of the control group was (81.31±5.32)， the difference was statistically significant (P＜0.05). Conclusion For those orthopedic patients undergoing major surgery， clinical comprehensive nursing after surgery can effectively prevent the formation of lower limb thrombosis， and patients are satisfied with the nursing work.