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为探讨新生儿期血清胆红素水平对远期预后的影响，对９０例新生儿高间接胆红素血症（简称高胆）患儿在５～８岁时进行了智商（ＩＱ）、听力及神经系统检查。结果显示，２３例（２５．６％）有程度不等的ＩＱ低下；１８例（２０．０％）有轻度听力障碍，以低频区为主；３例（３．３％）有神经系统异常。ＩＱ、听力及神经系统异常率与清血总胆红素峰值无显著相关性。约半数异常者血清总胆红素峰值＜２００ｍｇ／Ｌ。溶血组与非溶血组异常率差异无显著意义。提示，除重度高胆外，轻、中度高胆（无论是否溶血症）也可对新生儿产生永久性神经毒性作用，导致精神神经发育异常。单凭血清总胆红素水平并不能确切预测远期预后。对所有高胆新生儿均应积极治疗，以尽量减少后遗症的发生。
To investigate the effect of neonatal serum bilirubin on long-term prognosis, 90 neonates with high indirect bilirubin (IQ) children underwent IQ (IQ), hearing And neurological examination. The results showed that 23 cases (25.6%) had varying degrees of low IQ; 18 (20.0%) had mild hearing impairment, with low frequency; 3 cases (3.3%) had nervous system abnormal. IQ, hearing and nervous system abnormalities and serum total bilirubin peak no significant correlation. About half of abnormal serum total bilirubin peak <200mg / L. There was no significant difference in the abnormal rate between hemolysis group and non-hemolysis group. Tip, in addition to severe high gall, light, moderately high gall (whether or not hemolytic disease) can also have a permanent neonatal neurotoxic effect, leading to mental and neurological dysplasia. Total serum bilirubin alone does not predict long-term prognosis. All high-biliary neonatal should be actively treated to minimize the occurrence of sequelae.