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氰丙亚胺(BM12.531)为一调节宿主免疫反应的生物制剂。动物实验表明。此药可影响各种 T 淋巴细胞亚群表现型的表达,在体外和体内使活化巨噬细胞数中度增加,並通过促进粒细胞生成活性保护宿主对抗亚致死性全身放射和环磷酰胺的毒性。另外,此药可增加人类迟发型变态反应对回忆抗原相有丝分裂原的应答反应,中度增加骨髓瘤病人自然杀伤细胞活性。以往作者曾发现,此药可以促使淋巴细胞表现型
Cyanoimine (BM12.531) is a biological agent that modulates the host immune response. Animal experiments show. This drug can affect the expression of various T lymphocyte subset phenotypes, increase the number of activated macrophages in vitro and in vivo, and protect the host against sublethal systemic radiation and cyclophosphamide by promoting granulopoiesis activity. toxicity. In addition, this drug can increase the response of human delayed-type hypersensitivity to the mitogens of the recall antigen and moderately increase the natural killer cell activity of myeloma patients. Previous authors have found that this drug can promote lymphocyte phenotype