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通过亚硝酸法测定１９例神经母细胞瘤患儿血清锰超氧化物歧化酶（ＭｎＳＯＤ）活性。发现：神经母细胞瘤患儿血清ＭｎＳＯＤ活性显著高于其他恶性肿瘤组和正常对照组（Ｐ＜０．０１）；不同临床分期、病理分型的ＭｎＳＯＤ活性有明显差异；术后ＭｎＳＯＤ活性有一个显著的升高后再下降过程；ＭｎＳＯＤ活性在肿瘤复发后再度显著升高（Ｐ＜０．０１），且与预后关系密切。血清ＭｎＳＯＤ活性可作为神经母细胞瘤诊疗的参考指标。
Serum MnSOD activity was measured in 19 children with neuroblastoma by nitrous acid method. Findings: Serum MnSOD activity in children with neuroblastoma was significantly higher than other malignant tumors and normal controls (P<0.01); MnSOD activity was significantly different in different clinical stages and pathological types; postoperative MnSOD activity had one After a significant increase and then a decline in the process; MnSOD activity after tumor recurrence was significantly higher (P <0.01), and closely related to the prognosis. Serum MnSOD activity can be used as a reference indicator for diagnosis and treatment of neuroblastoma.