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目的探讨血浆五聚素3(PTX3)浓度与冠心病发生、发展的相关性。方法选取2013年6月~2014年12月我院60例冠心病(CHD)患者作为CHD组,其中急性心肌梗塞(AMI)组、稳定型心绞痛(SAP)组及不稳定型心绞痛(UAP)各20例,另选择20例健康体检者作为对照组,就四组患者的hs-CRP、PTX3水平及Genisin评分进行比较。同时对CHD近期预后的危险因素进行logistic回归分析。结果 CHD组患者的hs-CRP、PTX3及Genisin评分均明显高于对照组,差异有统计学意义(P<0.05),UAP组和AMI组在hs-CRP、PTX3及Genisin评分上与SAP组比较,差异均有统计学意义(P<0.05)。在hs-CRP及PTX3上,AMI组与UAP组比较,差异无统计学意义(P>0.05),两组Genisin评分比较,差异有统计学意义(P<0.05)。结论高血压、LDL-C、hs-CRP及PTX3是CHD近期预后的影响因素,伴有急性冠脉综合征的患者,其PTX水平明显升高,可作为早期诊断急性冠脉综合征的临床指标,对于CHD患者的预后评估也能发挥积极作用。
Objective To investigate the correlation between the plasma concentration of PTX3 and the occurrence and development of coronary heart disease. Methods Sixty CHD patients with coronary heart disease (CHD) from June 2013 to December 2014 in our hospital were enrolled in this study. The patients with acute myocardial infarction (AMI), stable angina (SAP) and unstable angina (UAP) 20 cases, another 20 healthy subjects were selected as the control group. The hs-CRP, PTX3 levels and Genisin scores were compared among the four groups. At the same time, the risk factors of the recent prognosis of CHD were analyzed by logistic regression. Results The hs-CRP, PTX3 and Genisin scores in CHD group were significantly higher than those in control group (P <0.05). The levels of hs-CRP, PTX3 and Genisin in UAP group and AMI group were significantly higher than those in SAP group , The differences were statistically significant (P <0.05). There was no significant difference between hs-CRP and PTX3 in AMI group and UAP group (P> 0.05). The difference of Genisin score between the two groups was statistically significant (P <0.05). Conclusions Hypertension, LDL-C, hs-CRP and PTX3 are the influential factors of the recent prognosis of CHD. The patients with acute coronary syndromes have significantly increased PTX levels, which may be used as an early clinical indicator in the diagnosis of acute coronary syndrome , For the prognosis of CHD patients can also play an active role.