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硝酸甘油过去只以舌下含服,近年来有采用皮肤软膏贴敷、口服持续释放剂,甚至气雾吸入。晚近认为硝酸甘油静脉注射是一种有价值的使用方法。制剂:将硝酸甘油片剂30或60毫克溶于50毫升无菌5%葡萄糖液内,用0.22微米的微孔过滤。然后再加至200毫升5%葡萄糖液中,以达到所需浓度,麻省大学医院所用制剂的浓度为120或240毫克/毫升。由于滴注剂量系根据血液动力学参数掌握,浓度稍有出入亦无妨。Lilly 药厂所生产的制剂
In the past, nitroglycerin was sublingual only. In recent years, skin ointment has been applied, oral sustained release agents and even aerosol inhalation. Recently that nitroglycerin intravenous injection is a valuable method of use. Formulation: Nitroglycerin tablets 30 or 60 mg were dissolved in 50 ml of sterile 5% dextrose solution and filtered through 0.22 micron micropores. This was then added to 200 ml of 5% dextrose solution to achieve the desired concentration, with a Mass Concentration of 120 or 240 mg / ml at the University of Massachusetts Hospital. Since the instillation dose is based on hemodynamic parameters, there is a slight discrepancy in concentration. Formulation produced by Lilly Pharmaceuticals