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【目的】探讨大株红景天注射液联合磺达肝葵钠预防老年骨折卧床患者下肢深静脉血栓形成（DVT ）的临床疗效。【方法】选择本院100例长期卧床的老年骨折患者（≥60岁），将其随机分为观察组（ n ＝50）和对照组（ n ＝50）。每组均皮下常规注射抗凝剂磺达肝葵钠，每日一次，治疗10 d ，观察组则在常规治疗的基础上，静脉滴注大株红景天注射液，每日一次，治疗10 d 。【结果】治疗10 d 后，观察组双下肢轻度肿胀发生率较对照组高，重度肿胀发生率低于对照组，双下肢重度疼痛发生率较对照组低，差异均有统计学意义（均 P ＜0．05）。对照组 DVT 发生率为10％，死亡率为4％，而观察组患者均未发生下肢 DVT ，差异具有统计学意义（ P ＜0．05）。【结论】大株红景天注射液联合磺达肝葵钠可安全、有效的防治老年因骨折卧床患者 DVT 。“,”Objective]To explore the efficacy and safety of treating lower extremity deep venous thrombo‐sis (DVT ) with Sofren Injection plus fondaparinux sodium in elderly bedridden patients after fractures .[Methods] A total of 100 elderly bedridden patients after fractures were randomized into observation ( n = 50) and control ( n = 50) groups .A daily subcutaneous injection of conventional anticoagulant fondaparinux sodi‐um was administered for a 10‐day course in both groups while the observation group received additionally an in‐travenous drip of Sofren Injection for another 10‐day course .[Results] After treatment ,the incidence of mild swelling of lower extremity was higher while that of severe swelling lower in observation group than control group .And the differences were statistically significant (both P < 0 .05) .The incidence of DVT was 10% and the mortality rate 4% in control group .And no DVT occurred in observation group .There were statistically significant differences .[Conclusion] Sofren Injection plus fondaparinux sodium are both safe and effective for preventing the occurrence of DVT in elderly bedridden patients after fractures .