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目的探讨非小细胞肺癌(NSCLC)短疗程适形非常规放疗同步EP方案化疗的疗效。方法Ⅲ期NSCLC患者68例,第1周采用适形常规放疗,2GY/次,照射5次,周六、日休息;然后采用常规大剂量放疗3GY/次,5次/周,照射10次;第4周与第1周治疗方式相同;第5周3GY/次,照射3次;共31d完成全部放疗,等效生物剂量为70GY。化疗采用EP方案:第1、2、3天VP-1680mg/m2,静脉滴注;第1天PDD60mg/m2静脉滴注。21d为1个周期,于照射当天同时行静脉化疗。同步放化疗结束后第3周再行3周期强化静脉化疗。结果近期有效率为89.7%,1、2、3年生存率为73.5%、39.7%、22.1%;中位生存期为19.6个月。结论短疗程适形非常规放疗同步EP方案化疗Ⅲ期NSCLC有较好疗效,不良反应可以耐受。
Objective To investigate the efficacy of short-course conformal radiotherapy (NSCLC) combined with EP regimen in non-small cell lung cancer (NSCLC). Methods A total of 68 patients with stage Ⅲ NSCLC were enrolled in this study. The patients were treated with conventional radiotherapy (2GY / time, 5 times a week) on the first week, and then rested on Saturdays and Sundays. Week 4 and week 1 treatment the same way; the first 5 weeks 3GY / time, irradiation 3 times; a total of 31 days to complete the radiotherapy, the equivalent biological dose of 70GY. Chemotherapy using EP regimen: first and second days VP-1680mg / m2, intravenous drip; PDD60mg / m2 intravenous drip on the first day. 21d for a cycle, the same day in the same vein irradiation chemotherapy. 3 weeks after the concurrent chemoradiation and then 3 cycles of intensive intravenous chemotherapy. Results The recent effective rate was 89.7%. The 1, 2, 3-year survival rates were 73.5%, 39.7% and 22.1%, respectively. The median survival time was 19.6 months. Conclusions Short-course conformal unconventional radiotherapy and concurrent EP regimen chemotherapy for stage III NSCLC have good curative effect and adverse reactions can be tolerated.